Top 10 Most Fuel-Efficient Hybrid Cars Published on May 20, 2019 in Top 10 by Frédéric Mercier Photo: Toyota 2. Toyota PriusThe Toyota Prius introduced North American drivers to hybrid cars when it launched here more than 20 years ago. Even today, it ranks as one of the most fuel-efficient with a combined rating of 4.4 L/100 km.